Author/Authors :
Lumbroso، نويسنده , , Alexandre and Coeffard، نويسنده , , Vincent and Le Grognec، نويسنده , , Erwan and Beaudet، نويسنده , , Isabelle and Quintard، نويسنده , , Jean-Paul، نويسنده ,
Abstract :
An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol has been reported starting from the commercially available (l)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50 g of the desired N-protected β-amino alcohols in 32% and 36% overall yields.
Keywords :
Chiral ?-amino alcohol , Amino acid , Vinylglycine , Preparative procedure
