Title of article
An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol
Author/Authors
Lumbroso، نويسنده , , Alexandre and Coeffard، نويسنده , , Vincent and Le Grognec، نويسنده , , Erwan and Beaudet، نويسنده , , Isabelle and Quintard، نويسنده , , Jean-Paul، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
3226
To page
3228
Abstract
An efficient and scalable synthesis of N-(benzyloxycarbonyl)- and N-(methyloxycarbonyl)-(S)-vinylglycinol has been reported starting from the commercially available (l)-methionine. The scale-up preparation consisted of 5 steps and delivered up to 50 g of the desired N-protected β-amino alcohols in 32% and 36% overall yields.
Keywords
Chiral ?-amino alcohol , Amino acid , Vinylglycine , Preparative procedure
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872353
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