Convenient supported recyclable material based on dihydrolipoyl-residue for the reduction of disulfide derivatives

A quantitative method for the reduction of disulfides, which uses a totally recyclable solid phase supported reducing agent, is reported. d,l-α-Lipoic acid was quantitatively condensed on a highly stable 100% PEG Aminomethyl-ChemMatrix® resin that can swell in aqueous media as well as in organic solvents. Lipoic residue, subsequently reduced to its dihydrolipoyl form, was utilized as a reducing agent for highly valuable disulfide compounds.