Author/Authors :
Li، نويسنده , , Miaosi and Fu، نويسنده , , Yingzi and Cui، نويسنده , , Xin and Chen، نويسنده , , Min and Liu، نويسنده , , Xiaohua and Lin، نويسنده , , Lili and Feng، نويسنده , , Xiaoming، نويسنده ,
Abstract :
A good chiral discrimination of lansoprazole (LAN) enantiomers was realized by a chiral N,N′-dioxide–Sc(III) complex, which was based on a fluorescent method through an ‘off-on’ process. The chiral ligand, N,N′-dioxide, coordinated with scandium(III) triflate forming an organic–metal complex as a chiral selector. Then the LAN enantiomers reacted with the selector and generated different signals in fluorescence. A distinct enantiomeric difference was observed with good repeatability, low detection limit, good linear range, and highly enantiomeric selectivity. At last, this study had offered a quantitative measurement of the enantiomer composition.
