Author/Authors :
Collins، نويسنده , , Michael Raymond and Huang، نويسنده , , Qinhua and Ornelas، نويسنده , , Martha A. and Scales، نويسنده , , Stephanie A.، نويسنده ,
Abstract :
A new method has been developed for the synthesis of 3-pyrazinyl-imidazo[1,2-a]pyridines. 2-Chloro-6-[(Z)-2-ethoxyethenyl]pyrazine was treated with N-bromosuccinimide in dioxane–water to generate the 2-bromo-2-(6-chloropyrazin-2-yl)-1-ethoxyethanol intermediate. In a subsequent one-pot step, optional treatment with various 2-aminopyridines provided the cyclized 3-pyrazinyl-imidazo[1,2-a]pyridines in 31–76% yields.
