Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction

A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.