Title of article
Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry
Author/Authors
Avitabile، نويسنده , , Concetta and Moggio، نويسنده , , Loredana and D’Andrea، نويسنده , , Luca D. and Pedone، نويسنده , , Carlo and Romanelli، نويسنده , , Alessandra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
3716
To page
3718
Abstract
An efficient and low-cost protocol for the manual synthesis of Peptide Nucleic Acids is reported here. The protocol relies on coupling reactions carried out with 2.5 equiv of PNA monomers activated with HOBT/HBTU, in the presence of pyridine/NMM. The protocol has been tested on four PNA oligomers with a length ranging from 9 to 12 bases and a purine content up to 67%.
Keywords
peptide nucleic acid , Manual synthesis , FMOC , pyridine
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1873477
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