Author/Authors :
Matsuo، نويسنده , , Jun-ichi and Okuno، نويسنده , , Ryosuke and Takeuchi، نويسنده , , Kosuke and Kawano، نويسنده , , Mizuki and Ishibashi، نويسنده , , Hiroyuki، نويسنده ,
Abstract :
Optimized reaction conditions for the preparation of various 2-monosubstituted 3-ethoxycyclobutanones are described. 2-Monoalkyl 3-ethoxycyclobutanones were efficiently prepared by the reaction of the corresponding carboxylic acid chlorides and an excess amount of ethyl vinyl ether in the presence of diisopropylethylamine at 90 °C in a sealed tube. 2-Monoaryl 3-ethoxycyclobutanones were prepared by using 2,6-lutidine as a base in the above-mentioned procedure.
