Author/Authors :
Nakamura، نويسنده , , Shuichi and Hayashi، نويسنده , , Masashi and Kamada، نويسنده , , Yasutoshi and Sasaki، نويسنده , , Ryosuke and Hiramatsu، نويسنده , , Yuichi and Shibata، نويسنده , , Norio and Toru، نويسنده , , Takeshi، نويسنده ,
Abstract :
A catalytic enantioselective desymmetrization of meso-N-(heteroarenesulfonyl)aziridines with TMSN3 using chiral Lewis acids afforded products with high enantioselectivity. As proof of the utility of this procedure, the precursor of selective κ-opioid agonist (1S,2S)-(−)-U-50,488 was synthesized.
Keywords :
Heteroarenesulfonyl groups , Stereocontroller , Chiral diamines , Chiral Lewis acids , Asymmetric catalysis
