Enantioselective synthesis of (+)-patulolide C via proline-catalyzed sequential α-aminooxylation and Horner–Wadsworth–Emmons olefination

The enantioselective total synthesis of (+)-patulolide C isolated from Penicillium urticae has been achieved from commercially available 9-decen-1-ol. Jacobsen’s kinetic resolution and sequential α-aminooxylation and Horner–Wadsworth–Emmons (HWE) olefination followed by Yamaguchi lactonization are used as the key reaction steps.