Title of article
Microbial transformation of (−)-Huperzine A
Author/Authors
Zhang، نويسنده , , Xinyuan and Zou، نويسنده , , Jianhua and Dai، نويسنده , , Jungui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
3840
To page
3842
Abstract
Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data. It is the first report on the microbial transformation of (−)-Huperzine A and would facilitate further structural modification by chemo-enzymatic method.
Keywords
(?)-Huperzine A , Microbial transformation
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1873599
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