Author/Authors :
Dietrich، نويسنده , , Justin and Kaiser، نويسنده , , Christine and Meurice، نويسنده , , Nathalie and Hulme، نويسنده , , Christopher، نويسنده ,
Abstract :
Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.
