Title of article
Diversity-oriented pyrazol-3-one synthesis based on hydrazinodipeptide-like units prepared via the Ugi reaction
Author/Authors
Lakontseva، نويسنده , , Ekaterina and Krasavin، نويسنده , , Mikhail، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4095
To page
4099
Abstract
N-Cyanoacetyl-N′-trifluoroacetyl-N′-alkylhydrazines, prepared via hydrazino-Ugi reaction, provided different pyrazol-3-ones when exposed to mildly acidic and mildly basic conditions at 60 °C. These approaches offer a facile access to two different pyrazol-3-one-containing chemotypes in a diversity-oriented fashion, in only two chemical operations from simple precursors.
Keywords
Post-Ugi modifications , Hydrazino-Ugi reaction , Monoalkylated pyrazol-3-ones , Peptidomimetics , diversity-oriented synthesis , Multi-component reactions
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1873850
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