Synthesis of C15–C27 segment of venturicidine X by utilizing desymmetrization protocol

We have achieved the synthesis of C15–C27 fragment of venturicidine X using desymmetrization protocol, substrate-controlled Grignard reaction, Barton–McCombie reaction, Sharpless epoxidation, and TBSOTf-mediated rearrangement to produce the aldol product through a non-aldol route as the key step following 23 longest linear sequences with 6.4% overall yield starting from a known intermediate 11.