Author/Authors :
Wu، نويسنده , , Shwu-Jen and Chan، نويسنده , , Hsiu-Hui and Hwang، نويسنده , , Tsong-Long and Qian، نويسنده , , Keduo and Morris-Natschke، نويسنده , , Susan and Lee، نويسنده , , Kuo-Hsiung and Wu، نويسنده , , Tian-Shung، نويسنده ,
Abstract :
Salviatalin A (1) and salvitrijudin A (2), two diterpenes with novel skeletons, were isolated from the roots of Salvia digitaloides. Their structures were determined using 1D, 2D NMR, and HRESI-MS spectroscopic analyses. Salviatalin A (1) from bioassay-guided fractionation showed a potent inhibitory effect on superoxide anion production in GMLP/CB-activated human neutrophils as well as other anti-inflammatory effects. A plausible biosynthetic pathway is also discussed.
Keywords :
Salvia digitaloides , Anti-inflammatory effects , Salvitrijudin A , Salviatalin A
