Title of article :
Optimization of a Pd-catalyzed intramolecular α-arylation synthesis of tricyclo-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones
Author/Authors :
Powell، نويسنده , , Noel A. and Hagen، نويسنده , , Timothy J. and Ciske، نويسنده , , Fred L. and Cai، نويسنده , , Cuiman and Duran، نويسنده , , Joseph E. and Holsworth، نويسنده , , Daniel D. and Leonard، نويسنده , , Daniele and Kennedy، نويسنده , , Robert M. and Edmunds، نويسنده , , Jeremy J.، نويسنده ,
Abstract :
We have optimized the Pd-catalyzed intramolecular α-arylation of 2-(2-halo-benzyl)-cyclohexanones and found that the use of 2-(dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl (X-Phos) as an added ligand led to a reproducible, efficient, and scalable synthesis of tricycle-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones.
