Synthesis of p38 MAP kinase inhibitor BIRB 796 and analogs via copper-mediated N-arylation reaction
Author/Authors :
Tan، نويسنده , , Zhulin and Song، نويسنده , , Jinhua J. and Reeves، نويسنده , , Jonathan T. and Fandrick، نويسنده , , Daniel R. and Lee، نويسنده , , Heewon and Campbell، نويسنده , , Scot and Yee، نويسنده , , Nathan K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
5
From page :
4547
To page :
4551
Abstract :
Direct N-arylation of urea (5) with various arylboronic acids mediated by cupric acetate furnished BIRB796 and a range of N-substituted BIRB796 analogs in good to moderate yields in one step. Urea (5) was readily synthesized from commercially available compounds.
