Title of article
Synthesis of the human aldose reductase inhibitor rubrolide L
Author/Authors
Boukouvalas، نويسنده , , John D. McCann، نويسنده , , Lucas C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
4636
To page
4639
Abstract
The first synthesis of rubrolide L, a marine ascidian butenolide and a potent inhibitor of human aldose reductase, has been achieved by two tactically distinct pathways in 4–5 steps and 37–42% overall yield from commercially available 3-chlorotetronic acid.
Keywords
diabetes , Selective bromination , Suzuki–Miyaura cross-coupling , Vinylogous aldol condensation
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874312
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