Title of article :
Pd2(dba)3-promoted synthesis of 3-N-substituted 4-aryl-1,2,3,6-tetrahydropyridine
Author/Authors :
Chang، نويسنده , , Meng-Yang and Lin، نويسنده , , Chung-Han and Chen، نويسنده , , Yeh-Long and Hsu، نويسنده , , Ru-Ting and Chang، نويسنده , , Ching-Yao، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
A novel method for the synthesis of 3-N-substituted 4-aryl-1,2,3,6-tetrahydropyridine 3 is presented. The process is carried out by the allylic bromination of 4-aryl-1,2,3,6-tetrahydropyridines 1 with N-bromosuccinimide in propanoic acid and palladium-catalyzed cross coupling of the corresponding bromide 2 with different N-based nucleophiles.
Keywords :
4-aryl-1 , 3 , 6-tetrahydropyridine , cross coupling , JohnPhos , 2 , N-Bromosuccinimide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
