Title of article :
The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde
Author/Authors :
Barfoot، نويسنده , , Christopher W. and Brown، نويسنده , , Pamela and Dabbs، نويسنده , , Steven and Davies، نويسنده , , David T. and Hennessy، نويسنده , , Alan J. and Miles، نويسنده , , Timothy J. and Pearson، نويسنده , , Neil D.، نويسنده ,
Abstract :
This Letter describes the synthetic routes to challenging pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde which were key intermediates for our antibacterial medicinal chemistry programme. All routes described started from kojic acid (8) and have been used to give multigram quantities of each aldehyde.
