Total synthesis of the fungal metabolite (±)-acremine G: acceleration of a biomimetic Diels–Alder reaction on silica gel

A total synthesis of the bioactive tetracyclic natural product acremine G has been achieved in which a regio- and stereoselective biomimetic Diels–Alder reaction between two readily assembled building blocks, accelerated on a solid support (silica gel), forms the key step.