Author/Authors :
Chandrasekhar، نويسنده , , S. and Balaji، نويسنده , , S.V. and Rajesh، نويسنده , , G.، نويسنده ,
Abstract :
The first total synthesis of achaetolide, a 10-membered macrolactone was achieved using Mitsunobu reaction and Grubbs ring-closing metathesis reaction as the key steps for ring construction. The desired stereo centres were generated by Jacobsen hydrolytic kinetic resolution, dihydroxylation and Sharpless asymmetric epoxidation reactions.
