Title of article :
Improved syntheses of precursors for PET radioligands [18F]XTRA and [18F]AZAN
Author/Authors :
Gao، نويسنده , , Yongjun and Wang، نويسنده , , Haofan and Mease، نويسنده , , Ronnie C. and Pomper، نويسنده , , Martin G. and Horti، نويسنده , , Andrew G.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
Improved syntheses of 7-methyl-2-exo-[3′-(2-bromopyridin-3-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptanes (3) and 7-methyl-2-exo-[3’-(6-bromopyridin-2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptanes (4), precursors for PET radioligands [18F]XTRA (1) and [18F]AZAN (2), involving a key Stille coupling step followed by deprotection of Boc group and N-methylation are described. The new synthetic procedures provided the title compounds in more than 40% overall yields.
Keywords :
Nachr , PET radioligand , Stille coupling , N-Methylation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
