Simple pyridylmethylamines: efficient and robust N,N-ligands for Suzuki–Miyaura coupling reactions

A series of pyridylmethylamines have been synthesized in one step from commercially available starting material and identified as effective ligands for Pd-catalyzed carbon–carbon bond formation through Suzuki–Miyaura coupling reaction. The N,N-pyridylmethylamine-Pd catalytic systems appeared as an interesting and robust compromise between catalytic efficiency, substrate compatibility, and practical aspects.