Title of article :
Synthesis and characterization of nucleobase functionalized monothiophenes
Author/Authors :
McTiernan، نويسنده , , Christopher D. and Chahma، نويسنده , , M’hamed، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
3
From page :
5483
To page :
5485
Abstract :
The synthesis of a series of nucleobase functionalized thiophene monomers has been accomplished through the reaction of 2-bromo-1-thiophen-3-yl-ethanone with the corresponding DNA base anion. The distinctive pKa values for the various amine groups in the nucleobases provided a pathway for the creation of specific anions through selective deprotonation of these groups. Using the appropriate anion it is possible to create an amine linkage between the thiophene and nucleobase that is, analogous to that found between the deoxyribose sugar and nucleobase, in the biologically occurring nucleoside.
Journal title :
Tetrahedron Letters
Serial Year :
2010
Journal title :
Tetrahedron Letters
Record number :
1875029
Link To Document :
بازگشت