Title of article :
The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic
Author/Authors :
Tatsuta، نويسنده , , Kuniaki and Tanaka، نويسنده , , Hiroaki and Tsukagoshi، نويسنده , , Hitomi and Kashima، نويسنده , , Takafumi and Hosokawa، نويسنده , , Seijiro، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael–Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.
Keywords :
total synthesis , Lactonamycin , glycosylation , thioester , Michael–Dieckmann type annulation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
