Title of article
TiCl4-promoted direct N-acylation of sulfonamide with carboxylic ester
Author/Authors
Fu، نويسنده , , Shaomin and Lian، نويسنده , , Xiaoyan and Ma، نويسنده , , Tongmei and Chen، نويسنده , , Wenhua and Zheng، نويسنده , , Meifang and Zeng، نويسنده , , Wei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5834
To page
5837
Abstract
Several Lewis acids were investigated as promoters in the intermolecular or intramolecular direct N-acylation reaction of sulfonamides using carboxylic ester as an acylating agent. TiCl4 was found to possess the highest activity and enhanced efficiently sulfonamide to form N-acylsulfonamides under optimized conditions. This method provides a novel approach to make N-acylsulfonamides from ester via an easy work-up procedure.
Keywords
N-acylation , N-Acylsulfonamide , Carboxylic ester , Lewis acid , acylating agents
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875316
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