Title of article
A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids
Author/Authors
Nagendra، نويسنده , , G. and Lamani، نويسنده , , Ravi S. and Narendra، نويسنده , , N. and Sureshbabu، نويسنده , , Vommina V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
6338
To page
6341
Abstract
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson’s reagent while 1,3,4-oxadiazoles are obtained by EDC mediated cyclodehydration.
Keywords
Peptidomimetics , cyclization , Thiadiazole , Diacylhydrazine , Oxadiazole
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875734
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