Author/Authors :
Koenig، نويسنده , , Stefan G. and Dankwardt، نويسنده , , John W. and Liu، نويسنده , , Yanbing and Zhao، نويسنده , , Hang and Singh، نويسنده , , Surendra P.، نويسنده ,
Abstract :
A variety of indole-2-carboxylic esters are accessible in yields up to 61% through a ligand-free, copper-catalyzed reaction of a series of commercially available 2-halo aryl aldehydes with benign glycine amidoesters, including the common reagent ethyl acetamidoacetate. This one-pot, three-reaction format allows ready entry to the desired heterocycles from starting substrates in the reactivity order of iodo > bromo ⩾ chloro substituents. An assortment of functional groups is tolerated, adding to the generality of this methodology.
