Title of article :
An efficient synthesis of α-methylene-γ-butyrolactones from Baylis–Hillman adducts via an In-mediated Barbier reaction and stereoselective lactonization under MeSO2Cl/Et3N conditions
Author/Authors :
Park، نويسنده , , Bo Ram and Kim، نويسنده , , Ko Hoon and Kim، نويسنده , , Jae Nyoung، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
An efficient synthesis of trans-α-methylene-γ-butyrolactones is disclosed from syn-homoallylic alcohols via the intramolecular mesylate displacement reaction promoted by nearby ester group under the influence of MsCl/Et3N. syn-Homoallylic alcohols were prepared via the In-mediated Barbier reaction of the bromides of Baylis–Hillman adducts.
Keywords :
?-Methylene-?-butyrolactones , Lactonization , Indium , Baylis–Hillman adducts , Barbier reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
