Author/Authors :
Liu، نويسنده , , Yongqiang and Nugroho، نويسنده , , Alfarius E. and Hirasawa، نويسنده , , Yusuke and Nakata، نويسنده , , Asami and Kaneda، نويسنده , , Toshio and Uchiyama، نويسنده , , Nahoko and Goda، نويسنده , , Yukihiro and Shirota، نويسنده , , Osamu and Morita، نويسنده , , Hiroshi and Aisa، نويسنده , , Haji Akber، نويسنده ,
Abstract :
Two novel elemanolide dimers, vernodalidimers A (1) and B (2), possessing a rare tricyclic ortho ester moiety, were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by 1D and 2D NMR data and CD spectra. Vernodalidimers A (1) and B (2) exhibited potent cell growth inhibitory activity against HL-60 cells (IC50 0.72 and 0.47 μM, respectively).
