Author/Authors :
LeClair، نويسنده , , Christopher A. and Boxer، نويسنده , , Matthew B. and Thomas، نويسنده , , Craig J. and Maloney، نويسنده , , David J.، نويسنده ,
Abstract :
A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki–Hiyama–Kishi (NHK) reaction to close the macrocycle at the C6′–C7′ bond.
