Author/Authors :
Herke، نويسنده , , Klلra and Hazai، نويسنده , , Lلszlَ and Sلnta، نويسنده , , Zsuzsanna and Dubrovay، نويسنده , , Zsَfia and Hلda، نويسنده , , Viktor and Szلntay Jr.، نويسنده , , Csaba and Kalaus، نويسنده , , Gyِrgy and Szلntay، نويسنده , , Csaba، نويسنده ,
Abstract :
Attempted cyclisation of N-methylated spiro benzazepine–cyclohexenone (5) into the corresponding N-methyl tetracyclic unit of galanthamine-type alkaloids (6) instead gave an unexpected rearrangement to yield a cyclopentanoisoquinolinone derivative (7). Methylation of the tetrahydrobenzofurobenzazepine tetracycle resulted in the expected N-methyl derivative 6, and the anomalous product 8, with structure similar to that of 7.
Keywords :
Cyclopentanoisoquinolinone , Amaryllidaceae alkaloids , Spirocyclohexenone , Rearrangement
