Title of article
Copper-catalyzed one-pot synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones from ortho-bromobenzamides and isothiocyanates
Author/Authors
Wang، نويسنده , , Fei and Zhao، نويسنده , , Peng-Ge Xi، نويسنده , , Chanjuan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
231
To page
235
Abstract
Copper-catalyzed tandem reaction of ortho-bromobenzamides and isothiocyanates is described, which provides an efficient and practical route for the synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones. The optimal condition involved the following parameters: CuI as precatalyst, Cs2CO3 as base, N,N′-dimethylethane-1,2-diamine as ligand, and toluene as solvent, with reaction temperature at 120 °C.
Keywords
3-Dihydroquinazolin-4(1H)-one , 2-Thioxo-2 , Tandem reaction , ortho-Bromobenzamides , Isothiocyanates
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876388
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