Author/Authors :
Cao، نويسنده , , Shi-Qi and Okamoto، نويسنده , , Itaru and Tsunoda، نويسنده , , Hirosuke and Ohkubo، نويسنده , , Akihiro and Seio، نويسنده , , Kohji and Sekine، نويسنده , , Mitsuo، نويسنده ,
Abstract :
We synthesized the 3′-phosphoramidite building block of 4-thiopseudoisocytidine (s4ΨiC) and incorporated it into triplex-forming oligonucleotides (TFOs). The results of thermal denaturation of triplexes incorporating s4ΨiC showed that s4ΨiC could be used as a nucleoside component of TFOs to increase the thermal stability of triplexes at pH 7.
Keywords :
4-Thiopseudoisocytidine , Triplex-forming oligonucleotides , Antigene , C-nucleoside , disulfide bond
