Author/Authors :
Higashino، نويسنده , , Masato and Ikeda، نويسنده , , Naoko and Shinada، نويسنده , , Tetsuro and Sakaguchi، نويسنده , , Kazuhiko and Ohfune، نويسنده , , Yasufumi، نويسنده ,
Abstract :
A novel silyl group-directed anti-SN2′ reaction of allylic alcohols under Mitsunobu reaction conditions is described. The Mitsunobu reaction of α-hydroxy-α-alkenylsilanes with a TBS or TIPS group gave the anti-SN2′ product, in which regio- and stereochemical outcomes of the reaction depended on the steric bulkiness of the silyl group.
