Title of article :
Synthesis of novel tetracyclo-isocoumarins via AcOH-catalyzed cascade reaction of heterocyclic ketene aminals with 2,2-dihydroxy-2H-indene-1,3-dione
Author/Authors :
Yan، نويسنده , , Sheng-jiao and Chen، نويسنده , , Yu-lan and Liu، نويسنده , , Lin and Tang، نويسنده , , Yajuan and Lin، نويسنده , , Jun، نويسنده ,
Abstract :
A facile synthesis of tetracyclo-isocoumarins based on the AcOH-catalyzed cyclocondensation and rearrangement reaction between heterocyclic ketene aminals and 2,2-dihydroxy-2H-indene-1,3-dione is described. This method provides direct access to tetacyclo-isocoumarins, a class of compounds with potential broad spectrum biological activities.
