Sequential oxidation/asymmetric aldol reaction of primary alcohols by resin-supported catalysts

The sequential reaction including alcohol oxidation by TEMPO/Cu system and the asymmetric aldol reaction by peptide catalysis was realized using resin-supported catalysts. The step of oxidizing primary alcohols to the corresponding aldehydes could be dramatically enhanced through the introduction of triglycyl peptide to supported TEMPO and the method of pre-adsorbing a Cu-complex into resin beads.