Author/Authors :
Finlayson، نويسنده , , Rhys and Brackovic، نويسنده , , Amira and Simon-Levert، نويسنده , , Annabel and Banaigs، نويسنده , , Bernard and O’Toole، نويسنده , , Ronan F. and Miller، نويسنده , , Christopher H. and Copp، نويسنده , , Brent R.، نويسنده ,
Abstract :
A stereospecific synthesis of both enantiomers of the marine alkaloid eudistomin X using the amino acid chiral pool is achieved. Comparison of 1H and 13C NMR chemical shifts of the synthetic product as either the free base, mono-salt or disalt with those reported for the natural product established that the ascidian metabolite was originally characterised as a mono-salt and that the absolute configuration was (10R).
Keywords :
Ascidian , Stereospecific synthesis , Chiral pool , biological activity , marine alkaloid , ?-Carboline
