Title of article :
Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb
Author/Authors :
Suresh، نويسنده , , G. and Babu، نويسنده , , K. Suresh and Rao، نويسنده , , V. Rama Subba and Rao، نويسنده , , M. Suri Appa and Nayak، نويسنده , , V. Lakshma and Ramakrishna، نويسنده , , Sistla، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes (1–3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1–3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC50 values of 0.04 and 0.18 μg/mL, respectively.
Keywords :
Premna latifolia , Icetexane diterpenes , cytotoxic activity , Cancer cell lines
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
