Author/Authors :
Lange، نويسنده , , Jos H.M. and Sanders، نويسنده , , Hans J. and van Rheenen، نويسنده , , Jeroen، نويسنده ,
Abstract :
A novel synthetic route to the highly selective and orally active cannabinoid CB1 receptor inverse agonist ibipinabant is described which combines the use of inexpensive, commercially available reagents and mild reaction conditions with a high degree of atom-efficiency. The method is expected to enable the rapid synthesis of a variety of sulfonylguanidines.
