Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald–Hartwig-type coupling forms the C–S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams.