Efficient synthesis of 1,3,5-trisubstituted benzenes via three Pd-mediated carbon–sulfur, carbon–nitrogen and carbon–carbon bond formation reactions

An efficient synthesis of 1,3,5-trisubstituted benzenes via a sequential Pd-mediated carbon–sulfur, carbon–nitrogen, and carbon–carbon bond formation reactions is reported. Selective amidation and sulfonamidation reactions are accomplished via Pd-catalyzed reactions between aryl chlorides and an acetamide or a methanesulfonamide.