Title of article
Synthesis of two isotopically labeled versions of NEDD8-activating enzyme (NAE) inhibitor
Author/Authors
Li، نويسنده , , Yuexian and Plesescu، نويسنده , , Mihaela and Prakash، نويسنده , , Shimoga R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
1807
To page
1810
Abstract
The synthesis of two isotopically labeled versions of an investigational NAE inhibitor (MLN4924) is reported. 14C-MLN4924 was synthesized from 14C-thiourea in eight steps. D8-MLN4924 was prepared from D9-3-phenylpropanoic acid in seven steps.
Keywords
NAE inhibitor , D8-(S)-1-aminoindan , MLN4924 , 14C-6-chloro-7-deazapurine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877626
Link To Document