Title of article
Structure–activity relationships of ustiloxin analogues
Author/Authors
Joullié، نويسنده , , Madeleine M. and Berritt، نويسنده , , Simon and Hamel، نويسنده , , Ernest، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
2136
To page
2139
Abstract
Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustiloxin D retained any activity.
Keywords
structure–activity relationships , Ustiloxin , tubulin polymerization , aziridine ring opening
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877839
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