Title of article
Microwave-assisted synthesis of nitrogen-containing 1-hydroxymethylenebisphosphonate drugs
Author/Authors
Mustafa، نويسنده , , Dana A. and Kashemirov، نويسنده , , Boris A. and McKenna، نويسنده , , Charles E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
2285
To page
2287
Abstract
A simple, rapid one-pot synthesis of heterocyclic (risedronate, zoledronate) and aminoalkyl (pamidronate, alendronate, neridronate) bisphosphonate drugs using microwave irradiation is presented. Good yields of product are achieved within 20 min, in contrast to conventional synthesis, which typically requires a day or longer.
Keywords
Microwave-assisted synthesis , bisphosphonates , Risedronate , Zoledronate , ALENDRONATE , Neridronate , Pamidronate
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877933
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