Title of article
Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes
Author/Authors
Kang، نويسنده , , Young Ku and Kim، نويسنده , , Dae Young، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
2356
To page
2358
Abstract
The catalytic enantioselective Mannich reaction promoted by chiral palladium complexes is described. The treatment of α-fluoro-β-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding β-aminated α-fluoro-β-ketoesters with excellent enantioselectivities (up to 99% ee).
Keywords
Mannich reaction , Chiral palladium catalysts , Asymmetric catalysis , ?-Fluoro-?-ketoesters , Aldimines
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877991
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