• Title of article

    Optimized synthesis of N-heterocyclic dronic acids; closing a black-box era

  • Author/Authors

    Keglevich، نويسنده , , Gyِrgy and Grün، نويسنده , , Alajos and Aradi، نويسنده , , Klلra and Garadnay، نويسنده , , Sلndor and Greiner، نويسنده , , Istvلn، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2011
  • Pages
    3
  • From page
    2744
  • To page
    2746
  • Abstract
    To clarify the inconsistent patent literature, the synthesis of Zoledronic and Risedronic acids involving a heterocyclic acetic acid (HAA), phosphorous acid (PA) and phosphorus trichloride (PC) as the reagents, and methanesulfonic acid as the solvent was studied in detail. It was found that the best synthesis can be accomplished at 80 °C using HAA and PC in a 1:3.1 molar ratio without any PA.
  • Keywords
    optimization , Rational synthesis , Mechanism , Dronic acids
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2011
  • Journal title
    Tetrahedron Letters
  • Record number

    1878299

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1878299