Author/Authors :
Maity، نويسنده , , Arindam and Mondal، نويسنده , , Shyamal and Paira، نويسنده , , Rupankar and Hazra، نويسنده , , Abhijit and Naskar، نويسنده , , Subhendu and Sahu، نويسنده , , Krishnendu B. and Saha، نويسنده , , Pritam and Banerjee، نويسنده , , Sukdeb and Mondal، نويسنده , , Nirup B.، نويسنده ,
Abstract :
A convenient and inexpensive one step methodology has been developed for the synthesis of linear and angular fused quinazolinones. The protocol, which uses amino heterocycles and o-bromo benzyl/naphthyl bromides as reactants, CuI as catalyst, Cs2CO3 as base, l-proline as ligand, and DMF as solvent, proceeds via nucleophilic aromatic substitution of the N-heteroaromatic cationic intermediate followed by in situ aerial oxidation at the benzylic position to the quinazolinone scaffold.
Keywords :
CuI , Cs2CO3 , Linear and angular annulated quinazolinones , L-proline
