Title of article :
A new approach to the synthesis of 4-(N-aryl)carbamoylmethyl-4,5-dihydropyridazin-3(2H)-ones
Author/Authors :
Stepakov، نويسنده , , Alexander V. and Kinzhalov، نويسنده , , Michail A. and Boitsov، نويسنده , , Vitaly M. and Stepakova، نويسنده , , Liubov V. and Starova، نويسنده , , Galina L. and Vyazmin، نويسنده , , Sergey Yu. and Grinenko، نويسنده , , Elena V.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Reaction of N-aryl substituted maleimides with aliphatic ketazines leads to the formation of 4,5-dihydropyridazin-3(2H)-ones in moderate yields. The reaction proceeds through 1,4-addition of an azine to the maleimide double bond, as confirmed by separation of the corresponding adducts in some cases, which are then converted into 4,5-dihydropyridazin-3(2H)-ones. In addition, the solid-state synthesis of 4,5-dihydropyridazin-3(2H)-ones is demonstrated for the first time.
Keywords :
4 , solvent-free conditions , 5-Dihydropyridazin-3(2H)-ones , Michael addition product , microwave irradiation , N-Arylmaleimides , Aliphatic ketazines
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
