Title of article
l-Proline as an efficicent catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in water
Author/Authors
Mecadon، نويسنده , , Hormi and Rohman، نويسنده , , Md. Rumum and Kharbangar، نويسنده , , Iadeishisha and Laloo، نويسنده , , Badaker M. and Kharkongor، نويسنده , , Icydora and Rajbangshi، نويسنده , , Mantu and Myrboh، نويسنده , , Bekington، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3228
To page
3231
Abstract
An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l-proline (10 mol %) in water under mild reaction condition in excellent yields is established. A comparative study of l-proline with γ-alumina, basic alumina, and KF-alumina was also carried out. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.
Keywords
L-proline , Environmentally benign , water , Four-component reaction
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878554
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